Skeletal Muscle Repair and Regeneration 2008_1

Skeletal Muscle Repair and Regeneration

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نوع فایل: پی دی اف

حجم فایل: 25 مگ

385 صفحه

مشاهده سبد خرید

توضیحات

Barring misfortune, there is a general expectation that our skeletal muscles will remain in effective service for our allotted ‘three-score- years-and-ten’ (Psalm 90, King James Bible, 1611) despite daily exposure to a variety of traumatic insults.

It is now clear that this maintenance entails efficient operation of appropriate repair processes. To cover the whole spectrum of severity of muscle injury ranging from i) focal intracellular damage, such as plasma membrane rupture or myofibril disruption, to ii) segmental damage or necrosis involving the whole length of individual muscle fibers, to iii) injuries affecting whole muscle bundles, including blood vessels and interstitial tissues, requires that these repair processes be subtly tailored to cope appropriately (Sloper et al., 1978). So ingrained, currently, is the notion that skeletal muscle can repair itself, that it comes as somewhat of a shock to be reminded (Chapter 1) how recently this idea has come into general acceptance and of how hot was the debate as to the fundamental mechanisms behind this repair process.

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